Endocrine Abstracts

Introduction: Human tear is rich in cytokines, i.e. in healthy individuals it exhibits a higher ratio of cytokines to total proteins than that in the serum of the same individual. EOP related to Graves–Basedow disease is thought to develop due to elevation of serum cytokine levels and to an altered cytokine response of the intra- and periorbital tissues. In our present study we focused on the measurement of IL6, IL8 and TNF-α, the relative amount of a lipocalin-type ...

Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and is thus the major site of peripheral insulin resistance. Urocortin 2 (Ucn2), a corticotropin releasing factor (CRF) family member and the type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle. To determine the physiological role of Ucn2, we generated mice deficient in this peptide. Using glucose and insulin tolerance tests and hyperinsulinemic euglycemic glucose clamp ...